Cactin

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CACTIN - Wikipedia. Cactin also known as renal carcinoma antigen NY-REN-24 is a protein that in humans is encoded by the CACTIN gene. Cactin was originally identified in Drosophila (fruit flies). The cactin gene is product is involved in the regulation of the innate immune system. It acts as negative regulator of the toll … See more. CACTIN Gene - GeneCards | CATIN Protein | CATIN Antibody. CACTIN (Cactin, Spliceosome C Complex Subunit) is a Protein Coding gene. Among its related pathways are Processing of Capped Intron-Containing Pre-mRNA. …. Cactin, a conserved protein that interacts with the Drosophila …. Cactin, a conserved protein that interacts with the Drosophila IkappaB protein cactus and modulates its function. 2000 Jun;94 (1-2):57-65. doi: 10.1016/s0925-4773 (00)00314-2. …

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. CACTIN is an essential nuclear protein in Arabidopsis …. CACTIN ( CTN) is highly conserved throughout eukaryotes [1] ( Fig. S1A ), but its function is largely unknown. CACTIN in most organisms contains a nuclear …. Cactin, a conserved protein that interacts with the …. A ProfileScan (Bucher et al., 1996) reveals that the protein contains three potential bipartite nuclear localization signals (bold in Fig. 3A) and three coiled-coil …. Cactin Targets the MHC Class III Protein IκB-like (IκBL) and …. Cactin (Cactus interactor) was initially discovered as a novel interactor of Drosophila Cactus, a regulator of Drosophila Toll signaling. Cactin Targets the MHC Class III …. Molecular characterization and functional analysis of Cactin gene …. Cactin (Cactus interactor) is a conserved protein which was initially discovered as a novel interactor of Drosophila IkB protein Cactus. Cactin was always characterized as a …. TmCactin plays an important role in Gram-negative and -positive .. While subsequent studies have identified the roles for Cactin in the mammalian immune response, the immune function of Cactin in insects has not been …. Entry - *618536 - CACTIN, SPLICEOSOME C COMPLEX …. CACTIN is conserved in plants and animals, and all CACTIN orthologs have a highly conserved region in their C-terminal halves. Northern blot analysis showed Cactin …. Human cactin interacts with DHX8 and SRRM2 to assure …. Cactin is required for cell cycle progression, genome stability and normal nuclear morphology in HeLa cells. HeLa cells were transfected with siCacD, siCacE and …. Molecular characterization and functional analysis of Cactin gene …. Cactin (Cactus interactor) is a conserved protein which was initially discovered as a novel interactor of Drosophila IkB protein Cactus

cactin

Cactin was always …. TmCactin plays an important role in Gram-negative and -positive .. Cactin was originally identified as an interactor of the Drosophila IκB factor Cactus and shown to play a role in controlling embryonic polarity and regulating the NF …. Cactin is essential for G1 progression in Toxoplasma gondii. Here we report on the characterization of a conserved protein, Cactin, and its role in the G1 stage of the Toxoplasma cell cycle

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. A forward genetic screen for temperature sensitive ( …

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. CACTIN is an Essential Nuclear Protein in Arabidopsis and may …. Cactin was originally identified as an interactor of the Drosophila IκB factor Cactus and shown to play a role in controlling embryonic polarity and regulating the NF …. Q8WUQ7 - UniProt. Involved in the regulation of innate immune response ( PubMed: 20829348 ). Acts as negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways ( PubMed: 20829348, PubMed: 26363554 ). Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in …. Border cell polarity and collective migration require the …. Border cells are an in vivo model for collective cell migration

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. Here, we identify the gene cactin as essential for border cell cluster organization, delamination, and migration

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. In Cactin-depleted cells, the apical proteins aPKC and Crumbs (Crb) become abnormally concentrated, and overall cluster polarity is lost.. CACTIN protein expression summary - The Human Protein Atlas. CACTIN INFORMATION. Proteini

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. Full gene name according to HGNC. Cactin, spliceosome C complex subunit. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC

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. CACTIN (C19orf29, fSAPc, NY-REN-24) Protein classi. Assigned HPA protein class (es) for the encoded protein (s).. Border cell polarity and collective migration require the …. Cactin is required for border cell delamination

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. (A–D) Confocal micrographs of c306-Gal4, UAS-LifeAct-GFP/+ egg chambers of the indicated stages

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. differential interference contrast imaging is shown in grayscale, DNA in blue, and GFP in green.(A′–D′) High-magnification images of the GFP channels for A–D. (E–H) Images of similar stage …. TmCactin plays an important role in Gram-negative and -positive .. Cactin was originally identified as an interactor of the Drosophila IκB factor Cactus and shown to play a role in controlling embryonic polarity and regulating the NF-κB signaling pathway. While .. Molecular characterization and functional analysis of Cactin gene …. To better know the immune function of Cactin gene, Litopenaeus vannamei Cactin (LvCactin) was identified and characterized in this study

. The full-length cDNA of LvCactin is 3, 150 bp long, with an open reading frame (ORF) encoding a Cactin_mid domain in the N-terminus 356–547 residues and a CactinC_cactus domain in the C …. CACN-1/Cactin interacts genetically with MIG-2 GTPase signaling …. CACN-1 is named after its fly homolog, Cactin, a Cactus/IKB interacting protein. Overexpression of Cactin enhances polarity defects in heterozygous cactus flies. The authors hypothesized Cactin may promote nuclear targeting of Dorsal/NFKB by destabilizing Cactus/IKB thereby leading to dorsal-ventral embryonic polarity defects (Lin …. Fission yeast Cactin restricts telomere transcription and …. Cactin and Rap1 proteins might genetically interact to modulate NF-κB-dependent gene expression programs, similar to what they do in fission yeasts to control expression of the telomeric transcriptome. Finally, Cactin deficiency results in substantial changes in the expression profile of a multitude of genes in T.. TRIM39 negatively regulates the NFκB-mediated signaling. In this study, to elucidate the function of TRIM39 in inflammatory signaling, we performed yeast two-hybrid screening using TRIM39 as a bait and identified Cactin, which has been reported to inhibit NFκB- and TLR-mediated transcriptions. We show that TRIM39 stabilizes Cactin protein and that Cactin is upregulated after TNFα stimulation.. UniProt. Involved in the formation of the dorsoventral pattern. It inhibits nuclear translocation of the dorsal morphogen in the dorsal region of the embryo. Acts as a negative regulator of the NF-kappa-B (rel) signaling pathway. Cact is degraded by IKKbeta, this is essential for NF-kappa-B (rel) activation.. Cactin, a conserved protein that interacts with the Drosophila …. Like the other components of this pathway, Cactin is evolutionarily conserved. Over-expression of cactin in a cactus(A2) heterozygous background results in the enhancement of the cactus phenotype. Both the embryonic lethality and ventralization are strongly increased, suggesting that cactin functions in the Rel pathway controlling the …. CACTIN - Wikipedia. Slično tome, CACTIN negativno regulira TLR-posredovanu aktivaciju IRF3 i IRF7 i indukciju gena koji reagiraju na IRF. Analize koimunoprecipitacije i imunofluorescencije pokazale su da CACTIN nije komunicirao s citoplazmatskom IKBA (NFKBIA), već je kolokalizirao i interakciju sa nuklearnim IKBL (NFKBIL1), za koji je utvrđeno da inhibira aktivaciju …. Cactin is essential for G1 progression in Toxoplasma gondii

cactin

Toxoplasma gondii is an obligate intracellular protozoan parasite whose rapid lytic replication cycles define its pathogenicity. We identified a temperature-sensitive growth mutant, FV-P6, which irreversibly arrests before the middle of the G1 stage of the tachyzoite cell cycle. This arrest is cause …

cactin

Cactin Targets the MHC Class III Protein IκB-like (IκBL) and …. We next attempted to address the mechanistic basis to the above described inhibitory effects of hCactin on TLR signaling. Given that Cactin was initially described in Drosophila as a protein-binding partner for the IκBα ortholog Cactus, we investigated the capacity of hCactin to interact with IκBα. Myc-tagged hCactin was thus overexpressed in …

cactin

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